Article
Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma.
Oncotarget - 31 May 2016
Bougnaud Sébastien, Golebiewska Anna, Oudin Anaïs, Keunen Olivier, Harter Patrick N, Mäder Lisa, Azuaje Francisco, Fritah Sabrina, Stieber Daniel, Kaoma Tony, Vallar Laurent, Brons Nicolaas H C, Daubon Thomas, Miletic Hrvoje, Sundstrøm Terje, Herold-Mende Christel, Mittelbronn Michel, Bjerkvig Rolf, Niclou Simone P
Abstract excerpt
The histopathological and molecular heterogeneity of glioblastomas represents a major obstacle for effective therapies. Glioblastomas do not develop autonomously, but evolve in a unique environment that adapts to the growing tumour mass and contributes to the malignancy of these neoplasms. Here, we show that patient-derived glioblastoma xenografts generated in the mouse brain from organotypic spheroids...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.