Article

Recurrent <i>FBXW7</i> mutations bypass Wnt/β-catenin addiction in cancer

2023-07-29

Abstract excerpt

Pathologic Wnt/β-catenin signaling drives various cancers, leading to multiple approaches to drug this pathway. Appropriate patient selection can maximize success of these interventions. Wnt ligand addiction is a druggable vulnerability in RNF43 -mutant/ RSPO -fusion cancers. However, pharmacologically targeting the biogenesis of Wnt ligands, e.g., with PORCN inhibitors, has shown mixed therapeutic responses, po...

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Literature Corpus work: 8fb7706b-18c4-5ff5-8a31-5d34947d965f
DOI: 10.1101/2023.07.28.550933

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