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Article

The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition.

Cancer research - 15 Dec 2020

Yu Jia, Yusoff Permeen A Mohamed, Woutersen Daniëlle T J, Goh Pamela, Harmston Nathan, Smits Ron, Epstein David M, Virshup David M, Madan Babita

Abstract excerpt

A subset of Wnt-addicted cancers are sensitive to targeted therapies that block Wnt secretion or receptor engagement. RNF43 loss-of-function (LOF) mutations that increase cell surface Wnt receptor abundance cause sensitivity to Wnt inhibitors. However, it is not clear which of the clinically identified RNF43 mutations affect its function in vivo. We assayed 119 missense and 45 truncating RNF43 mutations found in...

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Identifiers

PMID: 33067269
DOI: 10.1158/0008-5472.CAN-20-0957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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