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Article

Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/β-catenin addiction in cancer.

Science advances - 5 Apr 2024

Zhong Zheng, Virshup David M

Abstract excerpt

Pathologic Wnt/β-catenin signaling drives various cancers, leading to multiple approaches to drug this pathway. Appropriate patient selection can maximize success of these interventions. Wnt ligand addiction is a druggable vulnerability in RNF43-mutant/RSPO-fusion cancers. However, pharmacologically targeting the biogenesis of Wnt ligands, e.g., with PORCN inhibitors, has shown mixed therapeutic responses,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38569029
DOI: 10.1126/sciadv.adk1031
PMCID: PMC10990278

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