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Article

Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs.

Molecular cancer therapeutics - 1 May 2015

Madan Babita, Virshup David M

Abstract excerpt

Wnt signaling is dysregulated in many cancers and is therefore an attractive therapeutic target. The focus of drug development has recently shifted away from downstream inhibitors of β-catenin. Active inhibitors of Wnt secretion and Wnt/receptor interactions have been developed that are now entering clinical trials. Such agents include inhibitors of Wnt secretion, as well as recombinant proteins that minimize...

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Source

Identifiers

PMID: 25901018
DOI: 10.1158/1535-7163.MCT-14-1038

Genes

RNF43
RSPO2
RSPO3
ZNRF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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