Article

The functional landscape of patient derived RNF43 mutations predicts Wnt inhibitor sensitivity

2020-03-25

Abstract excerpt

A subset of Wnt-addicted cancers are sensitive to targeted therapies that block Wnt secretion or receptor engagement. RNF43 loss-of-function mutations that increase cell surface Wnt receptor abundance cause sensitivity to Wnt inhibitors. However, it is not clear which of the clinically identified RNF43 mutations affect its function in vivo . We assayed 90 missense and 45 truncating RNF43 mutations found in human...

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Literature Corpus work: 19297e0e-61e0-546e-885c-e3582c6c6f64
DOI: 10.1101/2020.03.25.006999

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