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Article

Meta-analysis of ALDH2 variants and esophageal cancer in Asians.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2011

Fang Ping, Jiao Shunchang, Zhang Xin, Liu Zhefeng, Wang Hongzhen, Gao Yan, Luo Hao, Chen Tao, Shi Li

Abstract excerpt

Alcohol drinking is considered a risk factor for esophageal cancer, and exposure to high levels of acetaldehyde, the principal metabolite of alcohol, may be responsible. Individuals homozygous for the *2 variant allele of aldehyde dehydrogenase 2 (ALDH2) are unable to metabolize acetaldehyde, which prevents them from alcohol drinking, whereas those with *1/*2 have a 6-fold higher blood acetaldehyde concentration...

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Identifiers

PMID: 22320964

Genes

ALDH2

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