Article

Identification of Immune complement function as a determinant of adverse SARS-CoV-2 infection outcome

2020-05-03

Abstract excerpt

<title>Abstract</title> <p>Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutics and public health intervention strategies. Viral-host interactions can guide discovery of regulators of disease outcomes, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of the coronavirus proteome. To determine if conditions...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f7a7157-5c65-5b8f-ac18-58dcac47f6ae
DOI: 10.21203/rs.3.rs-26451/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of Immune complement function as a determinant of adverse SARS-CoV-2 infection outcomeDOI 10.21203/rs.3.rs-26451/v1Read

Identification of Immune complement function as a determinant of adverse SARS-CoV-2 infection outcomeSemantic proximity Read

Complement dysregulation is a predictive and therapeutically amenable feature of long COVIDSemantic proximity Read

Rationale for targeting complement in COVID‐19Semantic proximity Read

CD55 upregulation in T cells of COVID-19 patients suppresses type-I interferon responsesSemantic proximity Read

Upregulation of CD55 complement regulator in distinct PBMC subpopulations of COVID-19 patients is associated with suppression of interferon responsesSemantic proximity Read

In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesisSemantic proximity Read

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19Semantic proximity Read

Complement dysregulation is a prevalent and therapeutically amenable feature of long COVIDSemantic proximity Read

MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19Semantic proximity Read

SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteinsSemantic proximity Read

Emerging role of complement in COVID-19 and other respiratory virus diseasesSemantic proximity Read

Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammationSemantic proximity Read