Article

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19

2022-09-30

Abstract excerpt

Abstract Complement, a critical defence against pathogens, has been implicated as a driver of pathology in COVID‐19. Complement activation products are detected in plasma and tissues and complement blockade is considered for therapy. To delineate roles of complement in immunopathogenesis, we undertook the largest comprehensive study of complement in COVID‐19 to date, comprehensive profiling of 16 complement biomar...

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Literature Corpus work: a66b2a02-9970-5dd3-ae99-cdbda9a9b086
DOI: 10.1111/imm.13585

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