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Article

SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins

13 Feb 2025

Abstract excerpt

Complement hyperactivation and thrombotic microangiopathy are closely associated with severe COVID-19. Endothelial dysfunction is a key mechanism underlying thrombotic microangiopathy. To address the relationship between endothelial injury, complement activation and thrombotic microangiopathy of severe COVID-19, we wonder whether, and if so, what and how SARS-CoV-2 factors make endothelial cells (ECs) sensitive...

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PMID: 39945674
DOI: 10.1080/22221751.2025.2467781

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