Article

Complement dysregulation is a predictive and therapeutically amenable feature of long COVID

2023-10-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Long COVID encompasses a heterogeneous set of ongoing symptoms that affect many individuals after recovery from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The underlying biological mechanisms nonetheless remain obscure, precluding accurate diagnosis and effective intervention. Complement dysregulation is a hallmark of acute COVID-19 but has...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37ccb74b-7750-555f-aacb-8a31d6fe0cc5
DOI: 10.1101/2023.10.26.23297597

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Complement dysregulation is a predictive and therapeutically amenable feature of long COVIDDOI 10.1101/2023.10.26.23297597Read

Complement dysregulation is a prevalent and therapeutically amenable feature of long COVIDSemantic proximity Read

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19Semantic proximity Read

Persistent Activation of Chronic Inflammatory Pathways in Long CovidSemantic proximity Read

Rationale for targeting complement in COVID‐19Semantic proximity Read

A complement atlas identifies interleukin-6–dependent alternative pathway dysregulation as a key druggable feature of COVID-19Semantic proximity Read

Complement control for COVID-19Semantic proximity Read

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisationSemantic proximity Read

Complement C3 vs C5 inhibition in severe COVID-19: early clinical findings reveal differential biological efficacySemantic proximity Read

Complement Inhibition and COVID-19: The Story so FarSemantic proximity Read

The complement system in COVID-19: friend and foe?Semantic proximity Read

Complement cascade in severe forms of COVID‐19: Recent advances in therapySemantic proximity Read

CD55 upregulation in T cells of COVID-19 patients suppresses type-I interferon responsesSemantic proximity Read