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Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation

10 Oct 2024

Abstract excerpt

Prenatal SARS-CoV-2 infection is associated with higher rates of pregnancy and birth complications, despite that vertical transmission rates are thought to be low. Here, multi-omics analyses of human placental tissues, cord tissues/plasma, and amniotic fluid from 23 COVID-19 mother-infant pairs revealed robust inflammatory responses in both maternal and fetal compartments. Pronounced expression of complement...

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PMID: 39390219
DOI: 10.1038/s44318-024-00260-9

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