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CD55 upregulation in T cells of COVID-19 patients suppresses type-I interferon responses

2 May 2025

Abstract excerpt

Complement overactivation, has been verified in COVID-19 patients. Complement regulatory proteins, including CD55, control complement overactivation thus eliminating complement deposition and cell lysis. We investigated complement regulatory protein expression in COVID-19 for potential deregulated expression patterns driving disease pathogenesis. Single-cell RNA-seq revealed increased PBMCs CD55 expression in...

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PMID: 40316776
DOI: 10.1038/s42003-025-08066-z

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