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In Vitro to In Vivo Concordance of Toxicity Using the Human Proximal Tubule Cell Line HK-2

29 Jul 2020

Abstract excerpt

The renal proximal tubule cell line, human kidney 2 (HK-2), recapitulates many of the functional cellular and molecular characteristics of differentiated primary proximal tubule cells. These features include anchorage dependence, gluconeogenesis capability, and sodium-dependent sugar transport. In order to ascertain how well HK-2 cells can reliably reveal the toxicological profile of compounds having a potential...

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PMID: 32723106
DOI: 10.1177/1091581820942534

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