Article

Novel Mechanism for Tubular Injury in Nephropathic Cystinosis

2022-05-13

Abstract excerpt

Understanding the unique susceptibility of the human kidney to pH dysfunction and injury in cystinosis is paramount to developing new therapies to preserve renal function. Renal proximal tubular epithelial cells (RPTECs) and fibroblasts isolated from patients with cystinosis were transcriptionally profiled. Lysosomal fractionation, immunoblotting, confocal microscopy, intracellular pH, TEM, mitochondrial stress te...

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Literature Corpus work: 1da2d6d6-ed1f-5999-8009-927ed18425d1
DOI: 10.1101/2022.05.13.491826

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