Article

Abnormal Chromatin Remodeling Caused by ARID1A Deletion Leads to Malformation of the Dentate Gyrus

2023-04-05

Abstract excerpt

<title>Abstract</title><p>ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer and hypothesized to be a tumor suppressor. Recently, loss-of-function of ARID1A gene has been shown to cause intellectual disability. Here we generate<italic>Arid1a</italic>conditional knockout mice and investigate<italic>Arid1a</italic>function in the hippocampus. Disruption of<italic>Arid1a</italic>in mouse fore...

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Literature Corpus work: 8f72cca1-0700-5e09-bce7-25765a5fc5b0
DOI: 10.21203/rs.3.rs-2735113/v1

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