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Article

Chromatin remodeling mediated by ARID1A is indispensable for normal hematopoiesis in mice

11 Mar 2019

Abstract excerpt

Precise regulation of chromatin architecture is vital to physiological processes including hematopoiesis. ARID1A is a core component of the mammalian SWI/SNF complex, which is one of the ATP-dependent chromatin remodeling complexes. To uncover the role of ARID1A in hematopoietic development, we utilized hematopoietic cell-specific deletion of Arid1a in mice. We demonstrate that ARID1A is essential for maintaining...

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PMID: 30858552
DOI: 10.1038/s41375-019-0438-4

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