Article

Genome-wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells

2020-05-08

Abstract excerpt

<h4>Background</h4> Early human heart and brain development simultaneously occur during embryogenesis. Notably, in human newborns, congenital heart defects strongly associate with neurodevelopmental abnormalities, suggesting a common gene/complex underlying both cardiogenesis and neurogenesis. However, due to lack of in vivo studies, the molecular mechanisms that govern both early human heart and brain developme...

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Literature Corpus work: b45a3e05-e308-527e-987b-afe3f1c2ce9e
DOI: 10.1101/2020.05.07.083113

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