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Article

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice.

Nature genetics - 1 Feb 2017

Mathur Radhika, Alver Burak H, San Roman Adrianna K, Wilson Boris G, Wang Xiaofeng, Agoston Agoston T, Park Peter J, Shivdasani Ramesh A, Roberts Charles W M

Abstract excerpt

Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are collectively mutated in ∼20% of all human cancers. Although ARID1A is the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenesis is unclear. Here we demonstrate that Arid1a functions as a tumor suppressor in the mouse colon, but not the small intestine, and that invasive ARID1A-deficient...

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Identifiers

PMID: 27941798
DOI: 10.1038/ng.3744
PMCID: PMC5285448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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