Article

ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial to mesenchymal transition in cranial neural crest lineage commitment

2024-04-03

Abstract excerpt

The BAF chromatin remodeler regulates lineage commitment including cranial neural crest cell (CNCC) specification. Variants in BAF subunits cause Coffin-Siris Syndrome (CSS), a congenital disorder characterized by coarse craniofacial features and intellectual disability. Approximately 50% of CSS patients carry variants in one of the mutually exclusive BAF subunits, ARID1A/ARID1B . While Arid1a deletion in mouse...

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Literature Corpus work: e8c7419a-25ed-589b-bb6d-4cced546355b
DOI: 10.1101/2024.04.03.587869

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