Article

An ALK1-governed monocytic lineage shapes an immunosuppressive landscape in breast cancer metastases

2024-06-17

Abstract excerpt

The biology centered around the TGF-β type I receptor ALK1 (encoded by ACVRL1) has been almost exclusively based on its reported endothelial expression pattern since its first functional characterization more than two decades ago. Here, in efforts to better define the therapeutic context in which to use ALK1 inhibitors, we uncover a population of tumor-associated macrophages (TAMs) that, by virtue of their unanti...

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Literature Corpus work: f4c47442-fa81-5036-9539-fc8c0c3bb7d8
DOI: 10.1101/2024.06.15.599147

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