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Article

An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis

8 Aug 2024

Abstract excerpt

We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment of heme and iron metabolism genes. These iron-rich tumor-associated macrophages (iTAMs) supported angiogenesis and immunosuppression in the tumor microenvironment and were conserved between mice and humans. iTAMs comprise two additional subsets based on gene expression profile and...

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PMID: 39347789
DOI: 10.1084/jem.20230420

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