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From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson's disease.

Translational neurodegeneration - 28 May 2026

Yu Zhenwei, Su Dongning, Li Siming, Lin Shinuan, Ren Kang, Feng Tao

Abstract excerpt

The definition of Parkinson's disease (PD) is undergoing a profound transformation from a "clinical syndrome" to a "biological entity", with development of two objective biological classification systems, the NSD-ISS (Neuronal Alpha-Synuclein Disease Integrated Staging System) and the SynNeurGe framework. Multimodal diagnostic tools further improve the detection of PD. This review synthesizes advances in three...

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Identifiers

PMID: 42210437
DOI: 10.1186/s40035-026-00558-0
PMCID: PMC13217808

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