Article

Gene-corrected Parkinson’s disease neurons show the A30P alpha-synuclein point mutation leads to reduced neuronal branching and function

2020-11-06

Abstract excerpt

Parkinson’s disease is characterised by the degeneration of A9 dopaminergic neurons and the pathological accumulation of alpha-synuclein. In a patient-derived stem cell model, we have generated dopaminergic neurons from an individual harbouring the p.A30P SNCA mutation and compared those neurons against gene-corrected isogenic control cell lines. We have used confocal microscopy to assess the neuronal network, spe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f125594-cdd6-5095-a2e4-20599ed1c284
DOI: 10.1101/2020.11.05.369389

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene-corrected Parkinson’s disease neurons show the A30P alpha-synuclein point mutation leads to reduced neuronal branching and functionDOI 10.1101/2020.11.05.369389Read

Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function.Semantic proximity Read

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics electrophysiological phenotype of the A53T mutationSemantic proximity Read

Global Effects of a PD Risk-SNP at the Alpha-Synuclein LocusSemantic proximity Read

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cellsSemantic proximity Read

Machine learning-aided multidimensional phenotyping of Parkinson’s disease patient stem cell-derived midbrain dopaminergic neuronsSemantic proximity Read

Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.Semantic proximity Read

Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the <i>SNCA</i> geneSemantic proximity Read

Neuronal hyperactivity in a LRRK2-G2019S cellular model of Parkinson’s DiseaseSemantic proximity Read

Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neuronsSemantic proximity Read

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays.Semantic proximity Read

Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons.Semantic proximity Read

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysisSemantic proximity Read