Back to search

Article

Lysine-Specific Demethylase 1 (LSD1) Modulates Hypoxia and Antitumor Immunity Pathways in Triple Negative Breast Cancer

2024-12-30

Abstract excerpt

<title>Abstract</title> <p>Epigenetic alterations can disrupt gene functions and lead to cellular neoplastic transformation, significantly contributing to cancer initiation and progression, including triple-negative breast cancer (TNBC). Inhibitors of lysine-specific demethylase 1 (LSD1) have shown potential antineoplastic activity, yet their utility as a biomarker and specific roles in TNBC remain underexplored....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2ff03b2c-2bc0-5514-bf06-f597d61d2601
DOI
10.21203/rs.3.rs-5583081/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Lysine-Specific Demethylase 1 (LSD1) Modulates Hypoxia and Antitumor Immunity Pathways in Triple Negative Breast CancerDOI 10.21203/rs.3.rs-5583081/v1
Increased Protein and Transcript Expression Levels of Lysine-Specific Demethylase 1 (LSD1) Signify Worse Prognosis in Triple-Negative Breast CancerSemantic proximity
Lysine-Specific Demethylase 1 (LSD1)-Mediated Epigenetic Modification of Immunogenicity and Immunomodulatory Effects in Breast CancersSemantic proximity
LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer.Semantic proximity
The tumour microenvironment in BRCA1/BRCA2 hereditary breast cancer and the role of epigenetics in its regulationSemantic proximity
High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patientsSemantic proximity
Comprehensive analysis of the associations of LOXL1-4 with prognosis and immune infiltration in breast cancerSemantic proximity
Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapySemantic proximity
LSM4 drives the progression of triple-negative breast cancer through alternative splicingSemantic proximity
E239K mutation abolishes the suppressive effects of lysine-specific demethylase 1 on migration and invasion of MCF7 cells.Semantic proximity
LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growthSemantic proximity
LSD1 inhibition corrects dysregulated MHC-I and dendritic cells activation through IFNγ-CXCL9-CXCR3 axis to promote antitumor immunity in HNSCCSemantic proximity
A multidimensional analysis of RAD1 as an immunological and prognostic biomarker in BRCASemantic proximity
Select a neighboring publication to make it the new centre.