Article

HYENA detects oncogenes activated by distal enhancers in cancer

2023-01-10

Abstract excerpt

Somatic structural variations (SVs) in cancer can shuffle DNA content in the genome, relocate regulatory elements, and alter genome organization. Enhancer hijacking occurs when SVs relocate distal enhancers to activate proto-oncogenes. However, most enhancer hijacking studies have only focused on protein-coding genes. Here, we develop a computational algorithm “HYENA” to identify candidate oncogenes (both protein-...

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Literature Corpus work: 71db960b-f403-5677-a57a-6aa05e1bdfb2
DOI: 10.1101/2023.01.09.523321

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