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Article

SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.

Genes & development - 15 Dec 2003

Dobreva Gergana, Dambacher Julia, Grosschedl Rudolf

Abstract excerpt

Nuclear matrix attachment regions (MARs) are regulatory DNA sequences that are important for higher-order chromatin organization, long-range enhancer function, and extension of chromatin modifications. Here we characterize a novel cell type-specific MAR-binding protein, SATB2, which binds to the MARs of the endogenous immunoglobulin micro locus in pre-B cells and enhances gene expression. We found that SATB2...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to Immunoglobulin mu-Chains

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Source

Open in PubMed Open full text

Identifiers

PMID: 14701874
DOI: 10.1101/gad.1153003
PMCID: PMC305257

Genes

SATB2
PIAS1
SATB1
SUMO1
SUMO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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