Article

Early Cancer Detection in Hereditary Breast and Ovarian Cancer Syndrome with Cell-Free DNA

2025-12-04

Abstract excerpt

Early cancer detection for individuals with Hereditary Breast and Ovarian Cancer syndrome (HBOC) remains limited by the low sensitivity of available tests and lack of clinical surveillance methods for many cancers beyond breast cancer. To investigate cell-free DNA (cfDNA) sequencing as a pan-cancer surveillance modality, we analyzed 194 blood plasma samples from 88 BRCA1 and/or BRCA2 pathogenic variant carriers...

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Literature Corpus work: 8e9ee0ff-a40c-59ba-ad96-3392e56eaf12
DOI: 10.64898/2025.12.03.25340892

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