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Article

Phenotypes from cell-free DNA.

Open biology - 1 Sept 2020

Zukowski Alexis, Rao Satyanarayan, Ramachandran Srinivas

Abstract excerpt

Cell-free DNA (cfDNA) has the potential to enable non-invasive detection of disease states and progression. Beyond its sequence, cfDNA also represents the nucleosomal landscape of cell(s)-of-origin and captures the dynamics of the epigenome. In this review, we highlight the emergence of cfDNA epigenomic methods that assess disease beyond the scope of mutant tumour genotyping. Detection of tumour mutations is the...

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Identifiers

PMID: 32873154
DOI: 10.1098/rsob.200119
PMCID: PMC7536073

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