Article

Integrated analysis of cell-free DNA for the early detection of cancer in people with Li-Fraumeni Syndrome

2022-10-11

Abstract excerpt

<h4>Summary</h4> Despite advances in cancer therapeutics, early detection is often the best prognostic indicator for survival ( 1 ). People with Li-Fraumeni syndrome harbor a germline pathogenic variant in the tumor suppressor gene TP53 ( 2 ) and face a near 100% lifetime risk of developing a wide spectrum of, often multiple, cancers ( 3 ). TP53 mutation carriers routinely undergo intensive surveillance protocols...

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Literature Corpus work: a69a5461-c1c5-5c2e-aea9-9abd1b13da19
DOI: 10.1101/2022.10.07.22280848

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