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Article

Current and new frontiers in hereditary cancer surveillance: Opportunities for liquid biopsy.

American journal of human genetics - 5 Oct 2023

Farncombe Kirsten M, Wong Derek, Norman Maia L, Oldfield Leslie E, Sobotka Julia A, Basik Mark, Bombard Yvonne, Carile Victoria, Dawson Lesa, Foulkes William D, Malkin David, Karsan Aly, Parkin Patricia, Penney Lynette S, Pollett Aaron, Schrader Kasmintan A, Pugh Trevor J, Kim Raymond H

Abstract excerpt

At least 5% of cancer diagnoses are attributed to a causal pathogenic or likely pathogenic germline genetic variant (hereditary cancer syndrome-HCS). These individuals are burdened with lifelong surveillance monitoring organs for a wide spectrum of cancers. This is associated with substantial uncertainty and anxiety in the time between screening tests and while the individuals are awaiting results. Cell-free DNA...

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Identifiers

PMID: 37802042
DOI: 10.1016/j.ajhg.2023.08.014
PMCID: PMC10577078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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