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Methylation in cell-free DNA for early cancer detection

13 Apr 2018

Abstract excerpt

Liquid biopsies and, in particular, analysis of cell-free DNA (cfDNA), have emerged as a promising and potentially transformative non-invasive diagnostic approach in oncology [1, 2]. cfDNA is composed of fragmented DNA released by cells into the circulation, typically as a result of cell death. cfDNA found in the plasma of healthy patients is composed of germline DNA released by normal cells. In cancer patients,...

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PMID: 29668834
DOI: 10.1093/annonc/mdy134

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