Article

PIN1 isomerisation of BRCA1 promotes replication fork protection

2018-11-28

Abstract excerpt

BRCA1, BRCA2 and a subset of Fanconi’s Anaemia proteins act to promote RAD51-mediated protection of newly synthesised DNA at stalled replication forks from degradation by nucleases. How BRCA1 contributes, how it is regulated and whether replication fork protection relates to, or differs from, the roles BRCA1 has in homologous recombination is not clear. Here we show that the canonical BRCA1-PALB2 interaction is no...

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Literature Corpus work: 8e962485-ed3e-5e25-87bb-19fa83624aed
DOI: 10.1101/478511

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