Article
BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.
Nature - 19 Oct 2017
Zhao Weixing, Steinfeld Justin B, Liang Fengshan, Chen Xiaoyong, Maranon David G, Jian Ma Chu, Kwon Youngho, Rao Timsi, Wang Weibin, Sheng Chen, Song Xuemei, Deng Yanhong, Jimenez-Sainz Judit, Lu Lucy, Jensen Ryan B, Xiong Yong, Kupfer Gary M, Wiese Claudia, Greene Eric C, Sung Patrick
Abstract excerpt
The tumour suppressor complex BRCA1-BARD1 functions in the repair of DNA double-stranded breaks by homologous recombination. During this process, BRCA1-BARD1 facilitates the nucleolytic resection of DNA ends to generate a single-stranded template for the recruitment of another tumour suppressor complex, BRCA2-PALB2, and the recombinase RAD51. Here, by examining purified wild-type and mutant BRCA1-BARD1, we show...
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