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Article

Translational control of breast cancer plasticity

2019-04-02

Abstract excerpt

Plasticity of neoplasia, whereby cancer cells attain stem-cell-like properties, is required for disease progression and represents a major therapeutic challenge. We report that in breast cancer cells NANOG , SNAIL and NODAL transcripts manifest multiple isoforms characterized by different 5’ Untranslated Regions (5’UTRs), whereby translation of a subset of these isoforms is stimulated under hypoxia. This leads...

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Identifiers and source

Literature Corpus work
8e955a12-a73f-51ee-91a9-0ca9738c7094
DOI
10.1101/596544
Open publication

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