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Article

E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer.

Cancer research - 1 Sept 2021

López-Menéndez Celia, Vázquez-Naharro Alberto, Santos Vanesa, Dubus Pierre, Santamaría Patricia G, Martínez-Ramírez Ángel, Portillo Francisco, Moreno-Bueno Gema, Faraldo Marisa M, Cano Amparo

Abstract excerpt

Cancer stem cells (CSC) are considered responsible for tumor initiation, therapeutic resistance, and metastasis. A comprehensive knowledge of the mechanisms governing the acquisition and maintenance of cancer stemness is crucial for the development of new therapeutic approaches in oncology. E2A basic helix-loop-helix (bHLH) transcription factors are associated with epithelial-mesenchymal transition (EMT) and...

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Identifiers

PMID: 34145034
DOI: 10.1158/0008-5472.CAN-20-2685
PMCID: PMC7611611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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