Article
Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia.
PloS one - 1 Jan 2013
D'Uva Gabriele, Bertoni Sara, Lauriola Mattia, De Carolis Sabrina, Pacilli Annalisa, D'Anello Laura, Santini Donatella, Taffurelli Mario, Ceccarelli Claudio, Yarden Yosef, Montanaro Lorenzo, Bonafé Massimiliano, Storci Gianluca
Abstract excerpt
Hypoxia has been long-time acknowledged as major cancer-promoting microenvironment. In such an energy-restrictive condition, post-transcriptional mechanisms gain importance over the energy-expensive gene transcription machinery. Here we show that the onset of hypoxia-induced cancer stem cell features requires the beta-catenin-dependent post-transcriptional up-regulation of CA9 and SNAI2 gene expression. In...
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