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Article

An Intricate Connection between Alternative Splicing and Phenotypic Plasticity in Development and Cancer.

Cells - 21 Dec 2019

Biamonti Giuseppe, Infantino Lucia, Gaglio Daniela, Amato Angela

Abstract excerpt

During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular environment (i.e., induced by anti-cancer drugs) elicit adaptive responses in cancer cells. Cellular plasticity increases the chance that tumor cells may survive in a challenging microenvironment, acquire new mechanisms of resistance to conventional drugs, and spread to distant sites. Re-activation of stem pathways appears as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31877720
DOI: 10.3390/cells9010034
PMCID: PMC7016785

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