Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition

19 Dec 2016

Abstract excerpt

Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown. Here, complementary studies in human tumors, cancer models and cell lines reveal transcriptional reprogramming that supports metastasis in response to mTOR inhibition. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Epigenetics and DNA Methylation
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27991928
DOI: 10.1038/onc.2016.427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibitionPMID 27991928Read ↗

Translational control of breast cancer plasticitySemantic proximity Read ↗

Oncofetal Reprogramming: A New Frontier in Cancer Therapy ResistanceSemantic proximity Read ↗

A SIRT1-centered circuitry regulates breast cancer stemness and metastasisSemantic proximity Read ↗

Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1Semantic proximity Read ↗

Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1Semantic proximity Read ↗

E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer.Semantic proximity Read ↗

Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast CancerSemantic proximity Read ↗

Targeting Osteosarcoma heterogeneity to improve therapeutic responseSemantic proximity Read ↗

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancerSemantic proximity Read ↗

Mechanisms of Breast Cancer Stem Cell Specification and Self-Renewal Mediated by Hypoxia-Inducible Factor 1Semantic proximity Read ↗

Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1Semantic proximity Read ↗

RASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.