Article

NF-κB-Inducing Kinase Maintains Mitochondrial Efficiency and Systemic Metabolic Homeostasis

2021-08-26

Abstract excerpt

<h4>Background</h4> NF-κB-inducing kinase (NIK) is a critical regulator of immunity and inflammation and NIK loss-of-function mutations have recently been described in patients with primary immunodeficiency disease. Based on our previous work showing that NIK regulates adaptive metabolic responses in glucose-starved cancer cells, we investigated whether NIK is required for mitochondrial functions in bioenergetic...

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Literature Corpus work: 8e833473-fec7-5918-b907-9d9dbd0a2536
DOI: 10.1101/2021.08.26.457753

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