Convergent Signals Encode Persistent Memory of Resilient States

Abstract excerpt

Caloric restriction reduces metabolic disease and associated comorbidities. Yet, the molecular mechanisms encoding cellular memory of these benefits remain unclear. Here, we use a functional genomics approach to integrate evolutionary cues, single-cell sequencing, and metabolomics, identifying convergent signals that encode epigenetic memory of adaptive states in visceral adipose tissue natural killer (NK) cells....

Topics

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• Adipokines, Inflammation, and Metabolic Diseases
• Adipose Tissue and Metabolism
• Bioinformatics and Genomic Networks
• Exercise and Physiological Responses
• Liver Disease Diagnosis and Treatment
• Metabolomics and Mass Spectrometry Studies

Identifiers and source

Literature Corpus work

0cdcb457-41ac-54bc-8fad-3b5b2fbe80ba

DOI

10.64898/2025.12.15.694462