Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion.

Cell reports - 1 Jun 2021

Mah-Som Annelise Y, Keppel Molly P, Tobin Joshua M, Kolicheski Ana, Saucier Nermina, Sexl Veronika, French Anthony R, Wagner Julia A, Fehniger Todd A, Cooper Megan A

Abstract excerpt

Natural killer (NK) cell effector functions are dependent on metabolic regulation of cellular function; however, less is known about in vivo metabolic pathways required for NK cell antiviral function. Mice with an inducible NK-specific deletion of Cox10, which encodes a component of electron transport chain complex IV, were generated to investigate the role of oxidative phosphorylation in NK cells during murine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylate Kinase
Share to Alkyl and Aryl Transferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens

Share to Cytomegalovirus Infections

Share to Immunologic Memory

Share to Muromegalovirus

Share to RNA-Seq

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 34077722
DOI: 10.1016/j.celrep.2021.109209
PMCID: PMC8229496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion.PMID 34077722Read ↗

Metabolic regulation of NK cell antiviral functions during cytomegalovirus infectionSemantic proximity Read ↗

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.Semantic proximity Read ↗

NF-κB-Inducing Kinase (NIK) Governs the Mitochondrial Respiratory Capacity, Differentiation, and Inflammatory Status of Innate Immune CellsSemantic proximity Read ↗

Distinct bioenergetic features of human invariant natural killer T (iNKT) cells enable retained functions in nutrient-deprived statesSemantic proximity Read ↗

Cytoplasmic NAD/H synthesis via NRK1 controls CD4+ T cell ROS homeostasis, regulating inflammatory capacity and promoting survivalSemantic proximity Read ↗

<sup>13</sup> C tracer analysis reveals the landscape of metabolic checkpoints in human CD8 <sup>+</sup> T cell differentiationSemantic proximity Read ↗

Glycolysis Is an Intrinsic Factor for Optimal Replication of a NorovirusSemantic proximity Read ↗

NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.Semantic proximity Read ↗

Targeting metabolism to reverse T-cell exhaustion in chronic viral infections.Semantic proximity Read ↗

NF-κB-Inducing Kinase Maintains Mitochondrial Efficiency and Systemic Metabolic HomeostasisSemantic proximity Read ↗

Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit To Drive Glycolytic Activation and Support Productive Viral InfectionSemantic proximity Read ↗

Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of oxygen reactive speciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.