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Article

Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis.

Cell reports - 4 Aug 2020

Henriques Felipe, Bedard Alexander H, Guilherme Adilson, Kelly Mark, Chi Jingyi, Zhang Peng, Lifshitz Lawrence M, Bellvé Karl, Rowland Leslie A, Yenilmez Batuhan, Kumar Shreya, Wang Yetao, Luban Jeremy, Weinstein Lee S, Lin Jiandie D, Cohen Paul, Czech Michael P

Abstract excerpt

Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregulate the sympathetic nerve fiber (SNF) modulator Neuregulin 4 (Nrg4), activate SNFs, and require adipocyte cyclic AMP/protein kinase A (cAMP/PKA) signaling for beige adipocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32755590
DOI: 10.1016/j.celrep.2020.107998
PMCID: PMC7433376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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