Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.

doi:10.1038/s41467-021-27704-8

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Article

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.

Nature communications - 12 Jan 2022

Schick Markus, Zhang Le, Maurer Sabine, Maurer Hans Carlo, Isaakaidis Konstandina, Schneider Lara, Patra Upayan, Schunck Kathrin, Rohleder Elena, Hofstetter Julia, Baluapuri Apoorva, Scherger Anna Katharina, Slotta-Huspenina Julia, Hettler Franziska, Weber Julia, Engleitner Thomas, Maresch Roman, Slawska Jolanta, Lewis Richard, Istvanffy Rouzanna, Habringer Stefan, Steiger Katja, Baiker Armin, Oostendorp Robert A J, Miething Cornelius, Lenhof Hans-Peter, Bassermann Florian, Chapuy Björn, Wirth Matthias, Wolf Elmar, Rad Roland, Müller Stefan, Keller Ulrich

Abstract excerpt

SUMOylation is a post-translational modification of proteins that regulates these proteins' localization, turnover or function. Aberrant SUMOylation is frequently found in cancers but its origin remains elusive. Using a genome-wide transposon mutagenesis screen in a MYC-driven B-cell lymphoma model, we here identify the SUMO isopeptidase (or deconjugase) SENP6 as a tumor suppressor that links unrestricted...

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PMID: 35022408
DOI: 10.1038/s41467-021-27704-8
PMCID: PMC8755833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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