Article

DNA i-motif levels are overwhelmingly depleted in living human cells: insights from in-cell NMR

2023-10-02

Abstract excerpt

I-Motifs (iM) are non-canonical DNA structures potentially forming in accessible, single-stranded, cytosine-rich genomic regions, with regulatory roles. Chromatin, protein interactions, and intracellular properties seem to govern iM formation at sites with i-motif formation propensity (iMFPS) in human cells, yet their specific contributions remain unclear. Using in-cell NMR with oligonucleotide iMFPS models, we mo...

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Literature Corpus work: 8e7888b9-325e-5ffc-9609-4381ad8f06e7
DOI: 10.1101/2023.10.01.558881

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