Article

Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin

2020-12-23

Abstract excerpt

<h4>Background: </h4> Brain-tumor-initiating cells (BTICs) of proneural and mesenchymal origin contribute to the highly malignant phenotype of glioblastoma (GB) and resistance to current therapies. <h4>Methods:</h4> BTICs of different subtypes representing tumor heterogeneity were challenged with OXPHOS (oxidative phosphorylation) inhibition to assess the differential effects of metabolic intervention on key resis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2b5ad11-6b6a-5caf-8ed1-67d11f868937
DOI: 10.21203/rs.3.rs-130871/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal OriginDOI 10.21203/rs.3.rs-130871/v1Read

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistanceSemantic proximity Read

The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring SequenceSemantic proximity Read

Molecular and cellular intratumoral heterogeneity in primary glioblastoma: clinical and translational implicationsSemantic proximity Read

Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of “metabolism‐based pathology”Semantic proximity Read

Integrative multi-omics Analysis Proposes a Metabolic Classification of Gliomas: Distinct Metabolic States, Immune Infiltration, and PrognosisSemantic proximity Read

Glioblastoma gene expression based subtypes have defined metabolomic statesSemantic proximity Read

Glioblastoma Metabolism: Insights and Therapeutic StrategiesSemantic proximity Read

Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging TargetSemantic proximity Read

Metabolic Rewiring in Glioblastoma Cancer: EGFR, IDH and BeyondSemantic proximity Read

Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptationsSemantic proximity Read

Glioblastomas: Hijacking Metabolism to Build a Flexible Shield for Therapy ResistanceSemantic proximity Read

The Acidic Brain—Glycolytic Switch in the Microenvironment of Malignant GliomaSemantic proximity Read