Article

The Warburg Effect Suppresses Ferroptosis Through Activation of NADPH Sensing

2026-06-08

Abstract excerpt

<title>Abstract</title> <p>Ferroptosis is an iron-dependent form of non-apoptotic cell death driven by catastrophic lipid peroxidation1,2. Sensitivity to ferroptosis in cancer is a hallmark of chemotherapy-resistant cells3,4,5 and low-density in vitro cultures6,7. Hypotheses for heightened ferroptosis sensitivity include the Hippo effectors YAP and TAZ7 and the adoption of a mesenchymal state5. However, whether a...

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Literature Corpus work: 3a83cd22-7765-53eb-be2a-d42c1437145c
DOI: 10.21203/rs.3.rs-9860072/v1

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