Article

Toxin-mediated depletion of nicotinamide dinucleotides drives persister formation in a human pathogen

2023-09-29

Abstract excerpt

Toxin-antitoxin (TA) systems are widespread in bacteria and are implicated in genome stability, virulence, phage defense and persistence. Although TA systems encompass a large variety of molecular activities and cellular targets, their physiological role and regulatory mechanisms are often unclear 1,2 . Here, we show that a RES domain TA system increases the survival of the human pathogen P. aeruginosa during an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e5e143e-bd14-50e8-8f49-c045450e39ac
DOI: 10.1101/2023.09.28.559889

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Toxin-mediated depletion of nicotinamide dinucleotides drives persister formation in a human pathogenDOI 10.1101/2023.09.28.559889Read

NAD+-targeting by bacteria: an emerging weapon in pathogenesisSemantic proximity Read

Characterization of NAD salvage pathways and their role in virulence in Streptococcus pneumoniaeSemantic proximity Read

Toxin-antitoxin systems in bacterial growth arrest and persistence.Semantic proximity Read

Widespread repurposing of the human CD38 ADP-ribosyl cyclase fold for toxicity in antibacterial and anti-eukaryotic bacterial polymorphic toxinsSemantic proximity Read

Molecular mechanisms and clinical implications of bacterial persistence.Semantic proximity Read

Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci.Semantic proximity Read

Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli.Semantic proximity Read

A <i>nadA</i> mutation confers nicotinic acid auxotrophy in pro-carcinogenic intestinal <i>Escherichia coli</i> NC101Semantic proximity Read

Type II Toxin-Antitoxin Systems: Evolution and Revolutions.Semantic proximity Read

NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymesSemantic proximity Read

NAD <sup>+</sup> metabolism is a key modulator of bacterial respiratory epithelial infectionsSemantic proximity Read

Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype.Semantic proximity Read