Article

Widespread repurposing of the human CD38 ADP-ribosyl cyclase fold for toxicity in antibacterial and anti-eukaryotic bacterial polymorphic toxins

2025-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Bacterial polymorphic toxins are modular weapons that mediate inter-microbial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems. Here, we identify and characterize a novel toxin domain in Pantoea ananatis that displays remarkable structural and functional conservation with the human enzyme CD38. This bacterial toxin, fused to the typ...

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Literature Corpus work: c6cbb4a1-129f-5cc4-9213-5c64a927ef5a
DOI: 10.1101/2025.07.23.666440

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