Article
Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jul 2013
Fasani Rick A, Savageau Michael A
Abstract excerpt
Toxin-antitoxin systems are ubiquitous and have been implicated in persistence, the multidrug tolerance of bacteria, biofilms, and, by extension, most chronic infections. However, their purpose, apparent redundancy, and coordination remain topics of debate. Our model relates molecular mechanisms to population dynamics for a large class of toxin-antitoxin systems and suggests answers to several of the open...
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